Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity. However, testosterone in physiologic doses might even be helpful in sufferers with angina , have larger ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood circulate in males with established coronary artery illness .
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- Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996).
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Unfortunately, the information on using excessive dose anabolic steroids in people are mainly offered as case reviews or small studies that lack adequate management groups. In addition, the data obtainable within the literature does not account for the steroid sort or dose, as neither may be identified. Patients additionally may be taking concomitant stimulants, such as ephedra, which might confound information and the potential for opposed occasions. It is likely that the frequency of cardiac occasions is underreported in the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which include more than 30 natural and synthetic derivatives of testosterone, might trigger a large spectrum of scientific sequalae.
We report a case of an acute ST-segment elevation myocardial infarction in a affected person with conventional cardiac risk components utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient also had polycythemia, likely secondary to high-dose testosterone. The affected person underwent successful percutaneous intervention of the right coronary artery. Physicians and patients ought to pay attention to the scientific consequences of anabolic steroid abuse.